Main article: Valproic acid

Sodium valproate
Systematic (IUPAC) name
sodium 2-propylpentanoate
Identifiers
CAS number	1069-66-5
ATC code	N03AG01
PubChem	14047
Chemical data
Formula	C8H15NaO2
Mol. mass	166.20
Pharmacokinetic data
Bioavailability	?
Protein binding	90-95%
Metabolism	75% by CYP enzymes
Half life	9 -18 hours
Excretion	20% excreted as glucuronide
Therapeutic considerations
Pregnancy cat.	D(AU) D(US)
Legal status	POM(UK) ℞-only(US)
Routes	oral, i.v.

Sodium valproate (INN) or valproate sodium (USAN) is the sodium salt of valproic acid and is an anticonvulsant used in the treatment of epilepsy; as well as being used as a mood stabilizer. The intravenous formulations are used when oral administration is not possible.

Formulations

US

• Intravenous injection – Depacon^® by Abbott Laboratories.
• Syrup – Depakene by Abbott Laboratories. (Note Depakene capsules are valproic acid).

UK & Australia

• Tablets – Orlept^® by Wockhardt and Epilim^® by Sanofi-Aventis.
• Oral solution – Orlept^® Sugar Free by Wockhardt and Epilim^® by Sanofi-Aventis.
• Syrup – Epilim^® by Sanofi-Aventis.
• Intravenous injection – Epilim^® Intravenous by Sanofi-Aventis.
• Extended release tablets – Epilim Chrono^® by Sanofi-Aventis. A combination of sodium valproate and valproic acid in a 2.3:1 ratio.
• Enteric-coated tablets – Epilim^® EC200 by Sanofi-synthelabo. A 200mg Sodium Valporate enteric-coated tablet.

Germany, Switzerland, Norway

• Tablets – Orfiril^® by Desitin Pharmaceuticals
• Intravenous injection – Orfiril^® IV by Desitin Pharmaceuticals

South Africa

• Syrup – Convulex^® by Byk Madaus

Canada

• Intravenous injection – Epival^® or Epiject^® by Abbott Laboratories.
• Syrup – Depakene^® by Abbott Laboratories. Generic formulations include Apo-Valproic and ratio-Valproic.

Others

In much of Europe, Depakine^® and Depakine Chrono^® are equivalent to Epilim and Epilim Chrono above.

See also

• Valproate semisodium

External links

• Chemical Land21: Sodium Valproate
• RXList.com: Depacon (Sodium Valproate)
• British National Formulary Edition 50
• Med Broadcast.com: Epival
• Drugs.com: Depaken Syrup